Project cost: £38,000

Much of our knowledge of how the human brain works and what happens in diseases such as Alzheimer’s disease (AD), Motor Neurone Disease (MND) or Parkinson’s disease (PD) has come from the study of human brain tissue. Comparing brain tissue from people with these devastating conditions with those who are unaffected is vital to understanding what is happening to the brain to produce that disease. A crucial method of comparing brain tissue and analysing brain disease is by examination under the microscope. A greater understanding of the brain changes in neurodegenerative diseases that are apparent at the level of microscopic examination is essential to identify novel disease targets and develop new treatment approaches.

microscopy

A state-of-the-art microscope and imaging system will enable researchers to perform a detailed characterisation of disease-associated brain structure and to analyse specific patterns of potential disease-related proteins, which are key components of many of the research projects. A high quality microscope is a core piece of equipment, central to the assessment of tissues for many projects and will be well used on a daily basis. A new modern microscope will also be invaluable for training young scientific and clinical research students within the department, who represent the future generation of neuroscience researchers, and will enable high quality data to be generated underpinning new discoveries and better treatments for a group of common devastating diseases.